| Date | Opponent | Location | Result | Record |
| Tuesday 11/9/21 (7 PM) | Fairfield | Providence, RI (Dunkin’ Donuts Center) | W 80-73 | 1-0 |
| Thursday 11/11/21 (6:30 PM) | Sacred Heart | Providence, RI (Dunkin’ Donuts Center) | W 92-64 | 2-0 |
| Monday 11/15/21 (9 PM) | Wisconsin | Madison, WI (Kohl Center) | W 63-58 | 3-0 |
| Thursday 11/19/21 (6:30 PM) | New Hampshire | Providence, RI (Dunkin’ Donuts Center) | W 69-58 | 4-0 |
| Monday 11/22/21 (9:30 PM) | Northwestern | Newark, NJ (Prudential Center) – Legends Classic | W 77-72 | 5-0 |
| Tuesday 11/23/21 (7:30 PM) | Virginia | Newark, NJ (Prudential Center) – Legends Classic | L 58-40 | 5-1 |
| Saturday 11/27/21 (12 PM) | Saint Peter’s | Providence, RI (Dunkin’ Donuts Center) | W 85-71 | 6-1 |
| Wednesday 12/1/21 (8:30 PM) | Texas Tech | Providence, RI (Dunkin’ Donuts Center) | W 72-68 | 7-1 |
| Saturday 12/4/21 (2 PM) | Rhode Island | Providence, RI (Dunkin’ Donuts Center) | W 66-52 | 8-1 |
| Tuesday 12/7/21 (6:30 PM) | Vermont | Providence, RI (Dunkin’ Donuts Center) | W 68-58 | 9-1 |
| Saturday 12/11/21 (2 PM) | Central Connecticut | Providence, RI (Dunkin’ Donuts Center) | W 68-53 | 10-1 |
| Saturday 12/18/21 (5 PM) | #20 UConn | Hartford, CT (XL Center) | W 57-53 | 11-1 |
| Wednesday 12/22/21 (6:30 PM) | Georgetown | Providence, RI (Dunkin’ Donuts Center) | PPD | PPD |
| Wednesday 12/29/21 (7 PM) | #15 Seton Hall | Providence, RI (Dunkin’ Donuts Center) | W 70-65 | 12-1 |
| Saturday 1/1/22 (2 PM) | DePaul | Chicago, IL (Wintrust Arena) | W 70-53 | 13-1 |
| Tuesday 1/4/22 (9 PM) | Marquette | Milwaukee, WI (Fiserv Forum) | L 88-56 | 13-2 |
| Saturday 1/8/22 (TBD) | St. John’s | Providence, RI (Dunkin’ Donuts Center) | W 83-73 | 14-2 |
| Tuesday 1/11/22 (9 PM) | Creighton | Omaha, NE (CHI Health Center Omaha) | PPD | PPD |
| Saturday 1/15/22 (2 PM) | UConn | Providence, RI (Dunkin’ Donuts Center) | PPD | PPD |
| Tuesday 1/18/22 (9 PM) | Seton Hall | Newark, NJ (Prudential Center) | PPD | PPD |
| Thursday 1/20/22 (5 PM) | Georgetown | Providence, RI (Dunkin’ Donuts Center) | W 83-75 | 15-2 |
| Sunday 1/23/22 (12 PM) | Butler | Providence, RI (Dunkin’ Donuts Center) | W 69-62 | 16-2 |
| Wednesday 1/26/22 (6:30 PM) | Xavier | Cincinatti, OH (Cintas Center) | W 65-62 | 17-2 |
| Saturday 1/29/22 (4:30 PM) | Marquette | Providence, RI (Dunkin’ Donuts Center) | W 65-63 | 18-2 |
| Tuesday 2/1/22 (9 PM) | St. John’s | Queens, NY (Carnesecca Arena) | W 86-82 | 19-2 |
| Sunday 2/6/22 (12 PM) | Georgetown | Washington D.C. (Capital One Arena) | W 71-52 | 20-2 |
| Saturday 2/12/22 (6:30 PM) | DePaul | Providence, RI (Dunkin’ Donuts Center) | W 76-73 OT | 21-2 |
| Tuesday 2/15/22 (8 PM) | #10 Villanova | Providence, RI (Dunkin’ Donuts Center) | L 89-84 | 21-3 |
| Sunday 2/20/22 (1 PM) | Butler | Indianapolis, IN (Hinkle Fieldhouse) | W 71-70 OT | 22-3 |
| Wednesday 2/23/22 (7 PM) | Xavier | Providence, RI (Dunkin’ Donuts Center) | W 99-92 3OT | 23-3 |
| Saturday 2/26/22 (8:30 PM) | Creighton | Providence, RI (Dunkin’ Donuts Center) | W 72-51 | 24-3 |
| Tuesday 3/1/22 (7 PM) | Villanova | Villanova, PA (Finneran Pavilion) | L 76-74 | 24-4 |
| Thursday 3/10/22 (12 PM) | Butler | New York, NY (Madison Square Garden) | W 65-61 | 25-4 |
| Friday 3/11/22 (6:30 PM) | Creighton | New York, NY (Madison Square Garden) | L 85-58 | 25-5 |
| Thursday 3/17/22 (12:40 PM) | SDSU | Buffalo, NY (KeyBank Center) | W 66-57 | 26-5 |
| Saturday 3/19/22 (6:10 PM) | Richmond | Buffalo, NY (KeyBank Center) | W 79-51 | 27-5 |
| Friday 3/25/22 (7:29 PM) | Kansas | Chicago, IL (United Center) | L 66-61 | 27-6 |
The Morning Hangover 